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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6409 | ALK kinase inhibitor-1 | SAR348830 | Others |
SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase. | |||
T3041 | ALK inhibitor 2 | FAK , ALK | |
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase. | |||
T10285 | ALK inhibitor 1 | FAK , IGF-1R , ALK | |
ALK inhibitor 1 is a selective ALK kinase inhibitor. | |||
T1967 | AZD-3463 | ALK/IGF1R inhibitor | Apoptosis , IGF-1R , ALK , Autophagy |
AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency. | |||
T3079 | GSK1838705A | IGF-1R , JNK , S6 Kinase , ALK | |
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases. | |||
T8152 | 6-Demethoxytangeretin | MAPK , ALK | |
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. | |||
T15612 | JH-VIII-157-02 | Microtubule Associated , ALK | |
JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-ALKwt, EML4-ALK C1156Y, EML4-ALK F1174L, and EML4-ALK F1174L... | |||
T11254 | F-1 | ROS , ALK , ROS Kinase | |
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathwa... | |||
T2612 | CEP-28122 | ALK | |
CEP-28122 is a highly potent and selective orally active ALK inhibitor. | |||
T4257 | Belizatinib | TSR-011 | Trk receptor , ALK |
Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC. | |||
T16153 | MS4078 | ALK , Ligand for E3 Ligase | |
MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK. | |||
T3059 | ALK-IN-1 | AP26113,Brigatinib,AP26113-analog | EGFR , IGF-1R , ALK |
ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2. | |||
T4071 | Repotrectinib | TPX-0005,TPX 0005,TPX0005 | Trk receptor , ROS , Src , ALK , ROS Kinase |
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively. | |||
T1962 | ASP3026 | ASP 3026 | Apoptosis , ALK |
ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS. | |||
T4015 | HG-14-10-04 | ALK | |
HG-14-10-04 is a potent and specific ALK inhibitor. | |||
T2655 | CEP-37440 | CEP37440 | FAK , ALK |
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK). | |||
T1791 | Ceritinib | LDK378 | Serine Protease , IGF-1R , ALK |
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM). | |||
T3621 | Brigatinib | AP-26113 | EGFR , FLT , ROS , IGF-1R , ALK |
Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor. | |||
T1661 | Crizotinib | PF-02341066 | c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase |
Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor. | |||
T3678 | Entrectinib | RXDX-101,NMS-E628 | Trk receptor , ROS , ALK , Autophagy , ROS Kinase |
Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectini... |